Hi ,

How are you doing today?

I'm sure you've heard a lot about how we are moving towards personalized medicine. Using chronotherapy is one such strategy that's showing remarkable promise.

I wanted to share findings from a research paper on the timing of blood pressure medication that could change how we treat hypertension. The study shows that when we take our blood pressure pills, the timing, might be just as important as the type of pills we take.

What is Chronotherapy?

Chronotherapy is the practice of administering medications in sync with your body's natural 24-hour biological clock, rather than taking them at any convenient time.

What Did This Study Discover?

This research followed over 5,000 people with high blood pressure for several years as part of the TIME (Treatment in Morning versus Evening) study. The results showed that:

• Night owls had fewer hospitalizations and heart attacks when they took their blood pressure medication in the evening rather than in the morning.
• Morning larks had fewer hospitalizations and heart attacks when they took their medication in the morning rather than the evening.
• The timing didn't affect stroke or heart failure rates - the benefit was specifically for heart attacks

This shows that matching your medication timing to your natural chronotype may reduce your risk of heart attack and hospitalization.

Understanding Chronotype - Your Personal Body Clock

Your "chronotype" is your body's natural preference for when to sleep and be active. We all have different natural rhythms that make us either "morning larks," "night owls," or somewhere in between.

Morning Larks:

• Wake up early naturally and feel alert in the morning
• Most energetic in the first half of the day
• Get tired earlier and prefer early bedtimes

Night Owls:

• Naturally stay up late and struggle with early mornings
• Feel more alert and energetic in the evening
• Prefer later bedtimes and naturally wake up later

How Did They Measure Chronotype?

The researchers used the Munich Chronotype Questionnaire (MCTQ), a detailed assessment of sleep patterns. However, you don't need a formal questionnaire to determine your chronotype. Most people already know whether they're naturally a morning lark or a night owl based on when they feel most alert and productive, with no schedule constraints.

What This Means for Your Health

The study found that when people took blood pressure medication at times that matched their chronotype, they had better outcomes. For example:

• Night owls might benefit from evening medication timing
• Morning larks might do better with morning doses
• The key is matching medication timing to YOUR personal body clock

Why This Research Matters

This study represents a shift from "one size fits all" medicine toward personalized treatment that considers an individual's unique biology. Instead of everyone taking blood pressure pills at the same time, we might move toward a timing that works with your body's natural rhythms.

This could lead to better blood pressure control and, as this study suggests, potentially fewer heart attacks.

Key Takeaways

• Always consult your healthcare provider before changing your medication timing, as they need to consider your specific medications and health conditions.
• Taking medications consistently is extremely important - whether morning or evening, stick to your prescribed schedule.
• Further research is needed to confirm these findings across different populations, but this discovery opens up exciting possibilities for personalized blood pressure treatment.

Best regards,

Shabnam

Reference:

Pigazzani, Filippo, et al. "Effect of timed dosing of usual antihypertensives according to patient chronotype on cardiovascular outcomes: the Chronotype sub-study cohort of the Treatment in Morning versus Evening (TIME) study." EClinicalMedicine 72 (2024).

Dr. Shabnam Das Kar, MD

Functional Medicine Doctor

Tiny Habits Coach

Email: info@drkarmd.com