Plenty of players need to have big performances if New Orleans defeats the 49ers. Here are the Saints players facing the biggest matchups.

The New Orleans Saints at San Francisco 49ers game preview, prediction, moneyline, and odds.

Trevor Penning and Bradley Roby are officially off of injured reserve and are available for Week 12's matchup against the 49ers.

A look at the top-five NFL teams in our power rankings, and the New Orleans Saints.

New Orleans to activate first-round pick Trevor Penning for their Week-12 game at San Francisco, per report.

Previewing a New Orleans passing game that should be productive against a disruptive 49ers pass defense, but must be consistent and avoid mistakes to pull off an upset.

New Orleans declares three players out and lists six as questionable for their Week 12 matchup at San Francisco, could get key defensive contributors back.

Previewing what will be a physical Week 12 war between the New Orleans running game and San Francisco run defense.

A New Orleans pass rush and coverage will be tested defensively by a San Francisco attack full of playmakers in a Week 12 showdown.

Alvin Kamara pops up on the second injury report of Week 12 for the Saints.